Calcium (S)-1-((S)-3-(((R)-2-(cyclohexanecarboxamido)propanoyl)thio)-2-methylpropanoyl)pyrrolidine-2-carboxylate
Names
[ CAS No. ]:
85921-53-5
[ Name ]:
Calcium (S)-1-((S)-3-(((R)-2-(cyclohexanecarboxamido)propanoyl)thio)-2-methylpropanoyl)pyrrolidine-2-carboxylate
[Synonym ]:
MC 838
altiopril calcium
Chemical & Physical Properties
[ Density]:
1.248g/cm3
[ Boiling Point ]:
658.9ºC at 760mmHg
[ Molecular Formula ]:
C38H58CaN4O10S2
[ Molecular Weight ]:
835.09600
[ Flash Point ]:
352.3ºC
[ Exact Mass ]:
834.32200
[ PSA ]:
236.16000
[ LogP ]:
4.58920
[ Storage condition ]:
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TW3620000
- CAS REGISTRY NUMBER :
- 85921-53-5
- LAST UPDATED :
- 199106
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C38-H58-N4-O10-S2.Ca
- MOLECULAR WEIGHT :
- 835.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >6 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920- Volume(issue)/page/year: 152,363,1987 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 40 gm/kg
- SEX/DURATION :
- male 60 day(s) pre-mating female 2 week(s) pre-mating female 1 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 18,3301,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2500 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 18,3335,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 625 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 18,3335,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 130 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 18,3325,1990
Related Compounds
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