1,3-Dipropyl-8-phenylxanthine

Names

[ Name ]:
1,3-Dipropyl-8-phenylxanthine

[Synonym ]:
dione,3,7-dihydro-1,3-dipropyl-8-phenyl-1h-purine-6
3,9-Dihydro-8-phenyl-1,3-dipropyl-1H-purine-2,6-dione
1,3-dipropyl-8-phenyl xanthine
NPC-200
3,7-dihydro-1,3-dipropyl-8-phenyl-1h-purine-2,6,dione

Biological Activity

[Description]:

NPC 200 is a potent and selective antagonist of Adenosine A1 Receptor. NPC 200 reverses NECA-induced left and right atrial depression with EC50s of 1.08 and 2.03 μM[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[References]

[1]. P. V. Kaplita, et al. NPC 205 is a potent and selective adenosine A1, receptor antagonist: Correlation among receptor binding, biochemical, and physiological assays. , 20(4), 429–443.

Chemical & Physical Properties

[ Density]:
1.218g/cm3

[ Boiling Point ]:
539.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₀N₄O₂

[ Molecular Weight ]:
312.36600

[ Flash Point ]:
279.8ºC

[ Exact Mass ]:
312.15900

[ PSA ]:
72.68000

[ LogP ]:
2.37330

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO8430880

CHEMICAL NAME :: 1H-Purine-2,6,dione, 3,7-dihydro-1,3-dipropyl-8-phenyl-

CAS REGISTRY NUMBER :: 85872-53-3

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5032593

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%