Azido-PEG8-amine

Names

[ Name ]:
Azido-PEG8-amine

[Synonym ]:
Azido-PEG-amine (n=8)
O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol
O-(2-Aminoethyl)-O inverted exclamation marka-(2-azidoethyl)heptaethylene glycol
26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-amine

Biological Activity

[Description]:

Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₈N₄O₈

[ Molecular Weight ]:
438.51600

[ Exact Mass ]:
438.26900

[ PSA ]:
149.61000

[ LogP ]:
0.54126

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Spatioselective Modification of Bicompartmental Polymer Particles and Fibers via Huisgen 1, 3‐Dipolar Cycloaddition Bhaskar S, et al.

Macromol. Rapid Commun. 29(20) , 1655-1660, (2008)