Tos-PEG3-O-C1-CH3COO

Names

[ Name ]:
Tos-PEG3-O-C1-CH3COO

Biological Activity

[Description]:

PROTAC Linker 6 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 6 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₄O₈S

[ Molecular Weight ]:
376.42

[ Storage condition ]:
2-8°C