1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-((1R)-(6-METHOXYQUINOLIN-4-YL)((2R,4S,5R)-5-VINYLQUINUCLIDIN-2-YL)METHYL)THIOUREA

Names

[ Name ]:
1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-((1R)-(6-METHOXYQUINOLIN-4-YL)((2R,4S,5R)-5-VINYLQUINUCLIDIN-2-YL)METHYL)THIOUREA

[Synonym ]:
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(R)-(6-methoxyquinolin-4-yl)-(8-vinylquinuclidin-2-yl)methyl]thiourea
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROPANOL-1 MIN.
1-[3,5-bis(trifluoromethyl)phenyl]-1-propanol
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROPANOL-1

Chemical & Physical Properties

[ Melting Point ]:
150°C

[ Molecular Formula ]:
C₂₉H₂₈F₆N₄OS

[ Molecular Weight ]:
594.61400

[ Exact Mass ]:
594.18900

[ PSA ]:
81.51000

[ LogP ]:
7.60690

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance.

Angew. Chem. Int. Ed. Engl. 44 , 6367-6370, (2005)

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Org. Lett. 7 , 1967-1969, (2005)

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

Related Compounds

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