ME-143

Names

[ Name ]:
ME-143

[Synonym ]:
3-(4-hydroxy-phenyl)-2-phenyl-thiazolidin-4-one
3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)chroman-7-ol
4-Thiazolidinone,3-(4-hydroxyphenyl)-2-phenyl

Biological Activity

[Description]:

ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

NADH oxidase[1]

[In Vitro]

ME-143 (0-100 μM; 48 hours) reduces proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and is more potent than Genistein[1]. Cell Proliferation Assay[1] Cell Line: RKO cell; DLD1 cell Concentration: 0-100 μM Incubation Time: 48 hours Result: Reduced proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and was more potent than Genistein.

[In Vivo]

NADH氧化酶抑制剂

[References]

[1]. Pintova S, et al. ME-143 Is Superior to Genistein in Suppression of WNT Signaling in Colon Cancer Cells. Anticancer Res. 2017;37(4):1647-1653.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈O₄

[ Molecular Weight ]:
334.36500

[ Exact Mass ]:
334.12100

[ PSA ]:
69.92000

[ LogP ]:
4.11150

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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