Cysmethynil

Names

[ Name ]:
Cysmethynil

[Synonym ]:
9J20
1H-Indole-3-acetamide, 5-(3-methylphenyl)-1-octyl-
2-[5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
Cysmethynil
1H-Indole-3-acetamide,5-(3-methylphenyl)-1-octyl

Biological Activity

[Description]:

Cysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[Target]

IC50 = 2.4 μM for Icmt

[References]

[1]. Winter-Vann AM, et al. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41.

[2]. Wang M, et al. A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J Biol Chem. 2008 Jul 4;283(27):18678-84.

[3]. Pan Q, et al. Inhibition of isoprenylcysteine carboxylmethyltransferase sensitizes common chemotherapies in cervical cancer via Ras-dependent pathway. Biomed Pharmacother. 2018 Mar;99:169-175.

[4]. Zhu C, et al. Targeting KRAS mutant cancers: from druggable therapy to drug resistance. Mol Cancer. 2022 Aug 4;21(1):159.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₂N₂O

[ Molecular Weight ]:
376.53400

[ Exact Mass ]:
376.25100

[ PSA ]:
49.01000

[ LogP ]:
7.15470

Related Compounds

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