Anti-inflammatory agent 49

Names

[ Name ]:
Anti-inflammatory agent 49

Biological Activity

[Description]:

nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 270 nM (dynamin-related protein 1 ,Drp1 )[1]

[References]

[1]. Luis Rios, et al. Targeting an allosteric site in dynaminrelated protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14(1):4356

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₂N₈O₃S

[ Molecular Weight ]:
466.52

Related Compounds

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