TAO Kinase inhibitor 2

Names

[ Name ]:
TAO Kinase inhibitor 2

[Synonym ]:
Benzamide, N-[2-oxo-2-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]ethyl]-4-phenoxy-
N-[2-Oxo-2-(1,2,3,4-tetrahydro-1-naphthalenylamino)ethyl]-4-phenoxybenzamide

Biological Activity

[Description]:

TAO Kinase inhibitor 2 (Example 49) is a TAO Kinase inhibitor (IC50=between 50 and 500 nM). TAO Kinase inhibitor 2 also inhibits KIAA1361 and JIK with IC50s of 50-500 nM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Cancer

[References]

[1]. Deborah Lynn Baly, et al. Tao kinase modulators and methods of use. Patent. WO2005040355.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
665.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₄N₂O₃

[ Molecular Weight ]:
400.47

[ Flash Point ]:
356.3±31.5 °C

[ Exact Mass ]:
400.178680

[ LogP ]:
5.96

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.644

Related Compounds

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