6-Methoxy-8-nitroquinoline
Names
[ CAS No. ]:
85-81-4
[ Name ]:
6-Methoxy-8-nitroquinoline
[Synonym ]:
6-Methoxy-8-nitroquinoline
Quinoline, 6-methoxy-8-nitro-
MFCD00006802
EINECS 201-633-7
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
373.1±27.0 °C at 760 mmHg
[ Melting Point ]:
158-160 °C(lit.)
[ Molecular Formula ]:
C10H8N2O3
[ Molecular Weight ]:
204.182
[ Flash Point ]:
179.4±23.7 °C
[ Exact Mass ]:
204.053497
[ PSA ]:
67.94000
[ LogP ]:
1.86
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.646
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VC0365000
- CHEMICAL NAME :
- Quinoline, 6-methoxy-8-nitro-
- CAS REGISTRY NUMBER :
- 85-81-4
- BEILSTEIN REFERENCE NO. :
- 0168992
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C10-H8-N2-O3
- MOLECULAR WEIGHT :
- 204.20
- WISWESSER LINE NOTATION :
- T66 BNJ HO1 JNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 nmol/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,11,1978
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335-H351
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R20/21/22;R36/37/38;R40
[ Safety Phrases ]:
S26-S27-S36/37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
VC0365000
[ HS Code ]:
2933499090
Synthetic Route
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. 12(10) , 2501-8, (2004)
We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most ...
Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline.J. Pharmacol. Exp. Ther. 297(2) , 509-15, (2001)
Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp. However, methemoglobinemia and hemolytic anemia are dose-limiting side effects of...