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Olmesartan lactone impurity

Names

[ CAS No. ]:
849206-43-5

[ Name ]:
Olmesartan lactone impurity

Biological Activity

[Description]:

Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

[References]

[1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.

[2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24N6O2

[ Molecular Weight ]:
428.48600

[ Exact Mass ]:
428.19600

[ PSA ]:
98.58000

[ LogP ]:
4.13650

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds