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Norgestrienone

Names

[ CAS No. ]:
848-21-5

[ Name ]:
Norgestrienone

[Synonym ]:
Ethynyl trienolone
Ogyline

Biological Activity

[Description]:

Norgestrienone, progestin or synthetic progestin, is a progestin receptor agonist. Norgestrienone is often used as a progestational compound in birth control pills and can be used in combination with ethinyl estradiol[1].

[Related Catalog]:

Signaling Pathways >> Others >> Progesterone Receptor
Research Areas >> Endocrinology

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
498.1ºC at 760 mmHg

[ Melting Point ]:
169ºC

[ Molecular Formula ]:
C20H22O2

[ Molecular Weight ]:
294.38700

[ Flash Point ]:
211.2ºC

[ Exact Mass ]:
294.16200

[ PSA ]:
37.30000

[ LogP ]:
3.33270

[ Index of Refraction ]:
1.615

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC8960080
CHEMICAL NAME :
19-Nor-17-alpha-pregna-4,9,11-trien-20-yn-3-one, 17-hydroxy-
CAS REGISTRY NUMBER :
848-21-5
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C20-H22-O2
MOLECULAR WEIGHT :
294.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
1168 ug/kg
SEX/DURATION :
female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,411,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
1642 ug/kg
SEX/DURATION :
female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,429,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
1 mg/kg
SEX/DURATION :
female 36 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 20,511,1979

Related Compounds