AAT-008

Names

[ Name ]:
AAT-008

[Synonym ]:
Benzoic acid, 4-[(1S)-1-[[[5-chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl]amino]ethyl]-
4-[(1S)-1-({[5-Chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl}amino)ethyl]benzoic acid

Biological Activity

[Description]:

A novel potent, and selective prostaglandin EP4 receptor antagonist with binding IC50 of 2.4 nM; shows little or no activity for hEP1/2/3 (IC50>1890 nM); inhibits PGE2-induced cAMP in human EP4 transfectant with pA2 of 8.97; exhibits significantly improved pharmacological profiles over grapiprant in acute and chronic inflammatory pain models in rats.

[References]

References 1. Okumura Y, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1186-1192. View Related Products by Target Prostaglandin Receptor

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
583.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₆ClFN₂O₄

[ Molecular Weight ]:
414.814

[ Flash Point ]:
306.6±30.1 °C

[ Exact Mass ]:
414.078278

[ LogP ]:
4.87

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds

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