Acetytastragaloside

Names

[ Name ]:
Acetytastragaloside

[Synonym ]:
β-D-Glucopyranoside, (3β,6α,9β,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-[(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)oxy]-9,19-cyclolanostan-6-yl
Acetytastragaloside
(3β,6α,9β,16β,20R,24S)-16,25-Dihydroxy-3-[(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside

Biological Activity

[Description]:

Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 9.5 μg/mL (T. brucei rhodesiense), 5.0 μg/mL (T. cruzi), ＞30 μg/mL (L. donovani), ＞20 μg/mL (P. falciparum), 24.2 μg/mL (L6 cells)[1]

[In Vitro]

Acetylastragaloside I (0.123-90 μg/mL; 72-96 h) shows in vitro antiprotozoal activity to T. brucei rhodesiense, T. cruzi, L. donovani and P. falciparum with IC50 values of 9.5, 5.0, ＞30 and ＞20 μg/mL, respectively[1]. Acetylastragaloside I (0.123-90 μg/mL; 72 h) exhibits cytotoxicity effects to rat skeletal myoblasts (L6) cells[1]. Cell Cytotoxicity Assay[1] Cell Line: Rat skeletal myoblasts (L6) cell line Concentration: 0.123-90 μg/mL Incubation Time: 72 hours Result: Showed cytotoxicity to L6 cells with an IC50 value of 24.2 μg/mL.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
902.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₇H₇₄O₁₇

[ Molecular Weight ]:
911.080

[ Flash Point ]:
254.5±27.8 °C

[ Exact Mass ]:
910.492615

[ PSA ]:
246.43000

[ LogP ]:
3.10

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.586

Precursor & DownStream

Precursor

DownStream

Related Compounds

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