BTS 54-505 hydrochloride

Names

[ Name ]:
BTS 54-505 hydrochloride

[Synonym ]:
MFCD03411585
Didesmethylsibutramine hydrochloride
Bts 54 505
Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, hydrochloride (1:1)
UNII:XJH8PK8XYH
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutan-1-amine hydrochloride (1:1)
Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, hydrochloride
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butanamine hydrochloride (1:1)
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

Biological Activity

[Description]:

Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Liu YL, et al. Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int J Obes Relat Metab Disord. 2002 Sep;26(9):1245-53.

[2]. Scott G, et al. The effects of BTS 54,505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. Br J Pharmacol. 1994 Jan;111(1):97-102.

Chemical & Physical Properties

[ Boiling Point ]:
337.9ºC at 760 mmHg

[ Melting Point ]:
160 - 166°C (lit.)

[ Molecular Formula ]:
C₁₅H₂₃Cl₂N

[ Molecular Weight ]:
288.26

[ Flash Point ]:
195.1ºC

[ Exact Mass ]:
287.120758

[ PSA ]:
26.02000

[ LogP ]:
5.63740

[ Storage condition ]:
Desiccate at RT

MSDS

Click to get detail MSDS

Related Compounds

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