Fructose 2,6-biphosphate sodium salt

Names

[ Name ]:
Fructose 2,6-biphosphate sodium salt

[Synonym ]:
Sodium 2-O-(hydroxyphosphinato)-6-O-phosphono-β-D-fructofuranose
D-(-)-fructose
D-Arabino-hexulose
D-Fructose 2,6-bisphosphate sodium salt
β-D-Fructofuranose, 2,6-bis(dihydrogen phosphate), sodium salt (1:1)
D-fructofuranose

Biological Activity

[Description]:

Fructose 2,6-biphosphate sodium salt is a potent stimulator of 6-Phosphofructo-1-kinase (PFK-1) and also inhibits Fructose-1,6-Bisphosphatase[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

PFK-1, Fructose-1,6-Bisphosphatase[1]

[In Vitro]

A concentration-dependent inhibition of fructose-1,6-Bisphosphatase by Fructose 2,6-bisphosphate is observed. Another characteristic of this inhibition is that it changes the saturation curve from hyperbolic to sigmoidal. This effect is clearly apparent at 25 pM Fructose 2,6-bisphosphate. It appears that the inhibitory actions of Fructose 2,6-bisphosphate and of AMP are synergistic. Indeed, at 10 pM fructose 1,6-bisphosphate, the addition of AMP alone causes a 35% inhibition but, it increases the inhibition by 1 pM Fructose 2,6-bisphosphate from 20% to 80%[1].

[References]

[1]. Van Schaftingen E, et al. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate. Proc Natl Acad Sci U S A. 1981 May;78(5):2861-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₄O₁₂P_2.xNa

[ Molecular Weight ]:
362.098

[ Exact Mass ]:
361.977997

[ PSA ]:
225.89000

Safety Information

[ Risk Phrases ]:
23/24/25-36/37/38-39/23/24/25

[ Safety Phrases ]:
26-36/37-45

Related Compounds

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