Prochlorperazine dimaleate
Names
[ CAS No. ]:
84-02-6
[ Name ]:
Prochlorperazine dimaleate
[Synonym ]:
stemetildimaleate
emetiral
Prochlorperazinbishydrogenmaleat
pasotomin
Prochlorperazine dimaleate,2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazinedimaleate
MFCD00069330
nibromina
Einecs 201-511-3
PROCHLORPERAZINE MALEATE
buctem
Prochlorperazine dimaleate
Vertigon
meterazinmaleate
PCZ-dimaleate
Chemical & Physical Properties
[ Boiling Point ]:
524.8ºC at 760 mmHg
[ Melting Point ]:
228ºC
[ Molecular Formula ]:
C28H32ClN3O8S
[ Molecular Weight ]:
606.08700
[ Flash Point ]:
271.2ºC
[ Exact Mass ]:
605.16000
[ PSA ]:
184.22000
[ LogP ]:
3.94460
[ Storage condition ]:
Store at RT
[ Water Solubility ]:
Very slightly soluble in water and in ethanol (96 per cent).
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO3150000
- CAS REGISTRY NUMBER :
- 84-02-6
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C20-H24-Cl-N3-S.2C4-H4-O4
- MOLECULAR WEIGHT :
- 606.14
- WISWESSER LINE NOTATION :
- T C666 BN ISJ EG B3- AT6N DNTJ D1 &OV1U1VO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 600 ug/kg/18H-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - muscle contraction or spasticity
- REFERENCE :
- SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 84,407,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,78,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 191 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 12,142,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,40,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 85 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 12,445,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5607 No. of Facilities: 84 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 4587 (estimated) No. of Female Employees: 4212 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312 + H332
[ Precautionary Statements ]:
P261-P280-P301 + P312 + P330
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
SO3150000
[ HS Code ]:
2934300000
Customs
[ HS Code ]: 2934300000
[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Neuropharmacology 36 , 665, (1997)
The effects of a range of phenothiazines were examined on 5-hydroxytryptamine3 (5-HT3) receptors in membranes from NIE-115 neuroblastoma cells using radioligand binding. Chlorpromazine, fluphenazine, ...