LTF4

Names

[ Name ]:
LTF4

[Synonym ]:
(5S,6R,7E,9E,11Z,14Z)-6-{[(2S)-2-{[(4S)-4-Amino-4-carboxy-1-hydroxybutylidene]amino}-2-carboxyethyl]sulfanyl}-5-hydroxy-7,9,11,14-icosatetraenoic acid
L-γ-Glutamyl-S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-L-cysteine
D-Cysteine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-
L-Cysteine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-
LTF4
Leukotriene F4
7,9,11,14-Eicosatetraenoic acid, 6-[[(2S)-2-[[(4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino]-2-carboxyethyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
L-γ-glutamyl-S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine
L-γ-Glutamyl-S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-D-cysteine

Biological Activity

[Description]:

Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family[1]. Leukotriene F4 induces bronchoconstriction with an ED50 of 16 μg/kg[2]. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

Research Areas >> Inflammation/Immunology

[Target]

Human Endogenous Metabolite

[References]

[1]. Reddanna P, et al. Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4. Arch Biochem Biophys. 2003;413(2):158-163.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
872.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₄₄N₂O₈S

[ Molecular Weight ]:
568.723

[ Flash Point ]:
481.6±34.3 °C

[ Exact Mass ]:
568.281860

[ PSA ]:
212.55000

[ LogP ]:
4.54

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.563

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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