Pafuramidine maleate

Names

[ Name ]:
Pafuramidine maleate

[Synonym ]:
DB289
Pafuramidine maleate
UNII-K27F04K3A9

Biological Activity

[Description]:

Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine (maleate) (DB289 (maleate)) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria[1][2][3].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Mdachi RE, et al. Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrob Agents Chemother. 2009 Mar;53(3):953-7.

[2]. Pohlig G, et al. Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. PLoS Negl Trop Dis. 2016 Feb 16;10(2):e0004363.

[3]. Chen D, et al. Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals. Expert Rev Anti Infect Ther. 2007 Dec;5(6):921-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₄N₄O₇

[ Molecular Weight ]:
480.47000

[ Exact Mass ]:
480.16400

[ PSA ]:
182.96000

[ LogP ]:
4.25940

Related Compounds

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