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RKRARKE

Names

[ CAS No. ]:
82801-73-8

[ Name ]:
RKRARKE

[Synonym ]:
L-Glutamic acid, N-(diaminomethylene)-L-ornithyl-L-lysyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-
Alg-Lys-Arg-Ala-Arg-Lys-Glu
cGMP-Dependent Protein Kinase Inhibitor Peptide
ARG-LYS-ARG-ALA-ARG-LYS-GLU
arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid
RKRARKE
PKG INHIBITOR
PROTEIN KINASE G INHIBITOR
N-(Diaminomethylene)-L-ornithyl-L-lysyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-glutamic acid
H-ARG-LYS-ARG-ALA-ARG-LYS-GLU-OH

Biological Activity

[Description]:

PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

Ki: 86 μM (PKG)[1]


[In Vitro]

Summary of experiments showing that intracellular dialysis of postsynaptic cells with PKG inhibitor PKG inhibitor peptide (1 mM) failed to alter the induction of long-term depression (CCh-LTD)[2].

[References]

[1]. Bhatnagar D, et al. Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry. 1988 Mar 22;27(6):1988-94.

[2]. Chiung-Chun Huang, et al. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010 Apr;20(4):982-96.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C38H74N18O10

[ Molecular Weight ]:
943.11

[ Exact Mass ]:
942.583557

[ PSA ]:
512.96000

[ LogP ]:
-5.78

[ Index of Refraction ]:
1.658

MSDS

Click to get detail MSDS

Related Compounds