2,6-dimethyl-1,3-dioxan-4-yl acetate
Names
[ CAS No. ]:
828-00-2
[ Name ]:
2,6-dimethyl-1,3-dioxan-4-yl acetate
[Synonym ]:
2,6-Dimethyl-1,3-dioxan-4-yl acetate
Acetomethoxane
EINECS 212-579-9
1,3-Dioxan-4-ol,2,6-dimethyl-,acetate
Dimethoxane,commercial grade
Caswell No. 363
GIV Gard DXN-CO
GIV Gard DXN
MFCD00069040
G1V Gard DXN
6-acetoxy-2,4-dimethyl-1,3-dioxane
6-acetoxy-2,4-dimethyl-m-dioxane
DIMETHOXANE
Chemical & Physical Properties
[ Density]:
1.067 g/mL at 25ºC(lit.)
[ Boiling Point ]:
66-68ºC/3 mmHg(lit.)
[ Molecular Formula ]:
C8H14O4
[ Molecular Weight ]:
174.19400
[ Flash Point ]:
52ºC
[ Exact Mass ]:
174.08900
[ PSA ]:
44.76000
[ LogP ]:
1.04700
[ Index of Refraction ]:
n20/D 1.433(lit.)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AH1350000
- CHEMICAL NAME :
- Acetic acid, ester with 2,6-dimethyl-m-dioxan-4-ol
- CAS REGISTRY NUMBER :
- 828-00-2
- BEILSTEIN REFERENCE NO. :
- 0128710
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 22
- MOLECULAR FORMULA :
- C8-H14-O4
- MOLECULAR WEIGHT :
- 174.22
- WISWESSER LINE NOTATION :
- T6O COTJ B1 DOV1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1930 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12 gm/kg/16D-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - changes in liver weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32500 mg/kg/13W-I
- TOXIC EFFECTS :
- Brain and Coverings - changes in brain weight Gastrointestinal - other changes Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 24 gm/kg/16D-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - changes in liver weight Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 948 gm/kg/88W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - leukemia
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25750 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 3660 ug/L
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-354,1989 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,177,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,177,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83665 No. of Facilities: 76 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 491 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83665 No. of Facilities: 11278 (estimated) No. of Industries: 114 No. of Occupations: 90 No. of Employees: 183978 (estimated) No. of Female Employees: 80381 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H302-H315-H319-H335-H351
[ Precautionary Statements ]:
P261-P281-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
36/37/38-40
[ Safety Phrases ]:
S22;S26;S36
[ RIDADR ]:
UN 1993
[ RTECS ]:
AH1350000
[ Packaging Group ]:
III
[ Hazard Class ]:
3.2
Synthetic Route
Articles
Photodermatol. 1(6) , 315-7, (1984)
Allergic contact dermatitis to dimethoxane in a spin finish.
Contact Dermatitis 6(6) , 421-4, (1980)
A textile worker exposed to dimethoxane in an aqueous system developed allergic contact dermatitis. Patch testing to this compound and its possible products in an aqueous system demonstrated sensitiza...