ISIS 329993

Names

[ CAS No. ]:
827355-42-0

[ Name ]:
ISIS 329993

Biological Activity

[Description]:

ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx?has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[References]

[1]. Warren MS, Hughes SG, Singleton W, Yamashita M, Genovese MC. Results of a proof of concept, double-blind, randomized trial of a second generation antisense oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis. Arthritis Res Ther. 2015;17(1):80.  

[2]. Noveck R, Stroes ES, Flaim JD, et al. Effects of an antisense oligonucleotide inhibitor of C-reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers. J Am Heart Assoc. 2014;3(4):e001084.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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