FEN1-IN-6

Names

[ CAS No. ]:
824983-84-8

[ Name ]:
FEN1-IN-6

Biological Activity

[Description]:

FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> FLAP

[References]

[1]. Tumey LN, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H8N2O5S2

[ Molecular Weight ]:
324.33

Related Compounds

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