STAT3 inhibitor C188

Names

[ Name ]:
STAT3 inhibitor C188

Biological Activity

[Description]:

A potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM) and inhibits IL-6-mediated phosphorylation of STAT3; inhibits nuclear translocation of phosphorylated Stat3 with IC50 of 39 uM, induces apoptosis preferentially of breast cancer cell lines with constitutive Stat3 activation.

[References]

References 1. Xu X, et al. PLoS One. 2009;4(3):e4783. View Related Products by Target STAT

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₅NO₇S₂

[ Molecular Weight ]:
433.449

Related Compounds

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