T988C

Names

[ Name ]:
T988C

Biological Activity

[Description]:

T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

T988C 抑制 P388 白血病细胞，ID50 为 0.56 μM[1]。

[References]

[1]. DeLorbe JE, et al. General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A. J Am Chem Soc. 2013 Mar 13;135(10):4117-28.

[2]. Feng Y, et al. Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp. J Nat Prod. 2004 Dec;67(12):2090-2.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₀N₄O₄S₂

[ Molecular Weight ]:
480.56

Related Compounds

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