d-Hexanolactone

Names

[ CAS No. ]:
823-22-3

[ Name ]:
d-Hexanolactone

[Synonym ]:
δ-Hexalactone
EINECS 212-511-8
MFCD00083574
d-Hexalactone
6-Methyltetrahydro-2-pyranone
6-methyloxan-2-one
6-Methyltetrahydro-2H-pyran-2-one
T6OVTJ F1
2H-Pyran-2-one, tetrahydro-6-methyl-

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
215.7±8.0 °C at 760 mmHg

[ Melting Point ]:
18ºC

[ Molecular Formula ]:
C₆H₁₀O₂

[ Molecular Weight ]:
114.142

[ Flash Point ]:
79.8±15.9 °C

[ Exact Mass ]:
114.068077

[ PSA ]:
26.30000

[ LogP ]:
0.29

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.431

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity

Bioorg. Med. Chem. 16 , 7504-9, (2008)

Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate rema...

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities.

J. Lipid Res. 46(6) , 1239-47, (2005)

The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and PON3. Their physiological role(s) and natural substrates are uncertain. We developed a baculovirus-mediated expression sy...

Lactonase and lactonizing activities of human serum paraoxonase (PON1) and rabbit serum PON3.

Biochem. Pharmacol. 66(6) , 887-96, (2003)

Human paraoxonase (PON1) was previously shown to hydrolyze over 30 different lactones (cyclic esters). In the present study purified human PON1 was found to catalyze the reverse reaction (lactonizatio...