Andrographoside

Names

[ Name ]:
Andrographoside

[Synonym ]:
[(1R,2R,4aS,5R,8aS)-2-Hydroxy-5-{(2E)-2-[(4S)-4-hydroxy-2-oxodihydro-3(2H)-furanylidene]ethyl}-1,4a-dimethyl-6-methylenedecahydro-1-naphthalenyl]methyl β-D-glucopyranoside
2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-5-[(β-D-glucopyranosyloxy)methyl]decahydro-6-hydroxy-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E,4S)-

Biological Activity

[Description]:

Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Kapil A, et al. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem Pharmacol. 1993 Jul 6;46(1):182-5.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
747.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₄₀O₁₀

[ Molecular Weight ]:
512.590

[ Flash Point ]:
247.2±26.4 °C

[ Exact Mass ]:
512.262146

[ PSA ]:
166.14000

[ LogP ]:
-0.41

[ Vapour Pressure ]:
0.0±5.6 mmHg at 25°C

[ Index of Refraction ]:
1.602

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

[Isolation and structure of two new diterpenoid glucosides from Andrographis paniculata Nees].

Yao Xue Xue Bao 17(6) , 435-40, (1982)

[Pharmacological studies on thirteen kinds of injections from Andrographis paniculata. I. Antipyretic, anti-inflammatory effects and toxicity].

Zhong Yao Tong Bao 10(7) , 38-42, (1985)

[Comprehensive evaluation of cuanhuning injection].

Zhongguo Zhong Yao Za Zhi 26(6) , 427-9, (2001)

Related Compounds

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