10Z-Hymenialdisine

Names

[ CAS No. ]:
82005-12-7

[ Name ]:
10Z-Hymenialdisine

[Synonym ]:
Hymenialdisine

Biological Activity

[Description]:

10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR

Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[In Vitro]

10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC50 value of 6 nM[1].

[References]

[1]. Ashraf N E Hamed, et al. Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri. Z Naturforsch C J Biosci. 2018 Apr 25;73(5-6):199-210.

Chemical & Physical Properties

[ Density]:
2.2 g/cm3

[ Melting Point ]:
160-164ºC

[ Molecular Formula ]:
C₁₁H₁₀BrN₅O₂

[ Molecular Weight ]:
324.13300

[ Exact Mass ]:
323.00200

[ PSA ]:
112.37000

[ LogP ]:
0.85980

[ Index of Refraction ]:
1.911

Precursor & DownStream

Precursor

DownStream

Related Compounds

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