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Ganoderic acid B

Names

[ CAS No. ]:
81907-61-1

[ Name ]:
Ganoderic acid B

[Synonym ]:
Ganoderic acid β
Ganoderic acid A
(7|A,15|A,25r)-7,15-dihydroxy-3,11,23-trioxolanost-8-en-26-oic acid
(3β,7β,25R)-3,7-Dihydroxy-11,15,23-trioxolanost-8-en-26-oic acid
ganoderic acid B
Lanost-8-en-26-oic acid, 3,7-dihydroxy-11,15,23-trioxo-, (3β,7β)-
Ganoderic acid
Lanost-8-en-26-oic acid, 3,7-dihydroxy-11,15,23-trioxo-, (3β,7β,25R)-
(3β,7β)-3,7-Dihydroxy-11,15,23-trioxolanost-8-en-26-oic acid
24,25-Dihydrolanosterol

Biological Activity

[Description]:

Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

[Target]

HIV-1 protease[3]


[References]

[1]. Zhou S, et al. Triterpenes and Soluble Polysaccharide Changes in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), During Fruiting Growth. Int J Med Mushrooms. 2018;20(9):859-871.

[2]. Zheng DS, et al. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Exp Ther Med. 2017 Oct;14(4):3273-3278.

[3]. el-Mekkawy S, et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry. 1998 Nov;49(6):1651-7.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
689.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H44O7

[ Molecular Weight ]:
516.666

[ Flash Point ]:
384.4±28.0 °C

[ Exact Mass ]:
516.308716

[ PSA ]:
128.97000

[ LogP ]:
2.33

[ Vapour Pressure ]:
0.0±4.9 mmHg at 25°C

[ Index of Refraction ]:
1.565

[ Storage condition ]:
-20C

Related Compounds