m-PEG5-nitrile

Names

[ CAS No. ]:
81836-41-1

[ Name ]:
m-PEG5-nitrile

Biological Activity

[Description]:

m-PEG5-nitrile is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Saifer MG, et al. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₂₃NO₅

[ Molecular Weight ]:
261.31

Safety Information

[ Hazard Codes ]:
Xi

m-PEG5-nitrile

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds