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(-)-Pinoresinol

Names

[ CAS No. ]:
81446-29-9

[ Name ]:
(-)-Pinoresinol

[Synonym ]:
2,6-di(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane
(+)-syringaresinol
pinoresinol monomethyl ether
pinoresinol
(7S,7'S,8R,8'R)-3,3'-dimethoxy-7,9':7',9-diepoxylignane-4,4'-diol

Biological Activity

[Description]:

(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Inflammation/Immunology

[References]

[1]. Lucia Fini, et al. Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. Carcinogenesis. 2008 Jan;29(1):139-46.  

[2]. Alexandrine During, et al. Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells. J Nutr. 2012 Oct;142(10):1798-805.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H22O6

[ Molecular Weight ]:
358.38500

[ Exact Mass ]:
358.14200

[ PSA ]:
77.38000

[ LogP ]:
3.19020

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds