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N-Nonyldeoxynojirimycin

Names

[ CAS No. ]:
81117-35-3

[ Name ]:
N-Nonyldeoxynojirimycin

[Synonym ]:
NN-DNJ
N-Nonyl-deoxynojirimycin
N-nonyl-1-deoxynojirimycin
Cromakalim
N-Nonyl-DNJ
N-(N-NONYL)DEOXYNOJIRIMYCIN

Biological Activity

[Description]:

N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of alpha-glucosidase and alpha-1,6-glucosidase (IC50s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: 0.42 μM (alpha-glucosidase), 8.4 μM (alpha-1,6-glucosidase)[1]


[References]

[1]. Andersson U, et al. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem Pharmacol. 2004 Feb 15;67(4):697-705.

Chemical & Physical Properties

[ Density]:
1.112g/cm3

[ Boiling Point ]:
451.7ºC at 760 mmHg

[ Melting Point ]:
101-102ºC

[ Molecular Formula ]:
C15H31NO4

[ Molecular Weight ]:
289.41

[ Flash Point ]:
224.5ºC

[ Exact Mass ]:
289.22500

[ PSA ]:
84.16000

[ LogP ]:
0.43410

[ Index of Refraction ]:
1.522

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds