ABT-102

Names

[ Name ]:
ABT-102

[Synonym ]:
N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea
(R)-1-(5-tert-butylindan-1-yl)-3-(1H-indazol-4-yl)
ABT-102

Biological Activity

[Description]:

ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

TRPV1

[References]

[1]. Lukin K, et al. Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102. Organic Process Research & Development, 2007, 11(3):578-584.

[2]. Rowbotham MC, et al. Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain. 2011 May;152(5):1192-1200.

Chemical & Physical Properties

[ Density]:
1.24 g/cm3

[ Boiling Point ]:
529.5ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₄N₄O

[ Molecular Weight ]:
348.44

[ Flash Point ]:
274.1ºC

[ Exact Mass ]:
348.19500

[ PSA ]:
69.81000

[ LogP ]:
5.13330

[ Storage condition ]:
2-8°C

ABT-102

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds