Fuziline

Names

[ Name ]:
Fuziline

[Synonym ]:
(1α,6α,10α,13ξ,14α,15α,16β,17ξ)-20-Ethyl-6,16-dimethoxy-4-(methoxymethyl)aconitane-1,8,14,15-tetrol
senbusine-C
Aconitane-1,8,14,15-tetrol,20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-,(1alpha,6alpha,14alpha,15alpha,16beta)
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1α,6α,10α,13ξ,14α,15α,16β,17ξ)-

Biological Activity

[Description]:

Fuziline is a alkaloid isolated from the lateral roots of Aconitum carmichaelii[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[In Vitro]

Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability[1].

[In Vivo]

Fuziline exhibits the mean half-life of 5.93 hours, 6.13 hours and 5.12 hours for 14 mg/kg, 2 4 mg/kg and 4 mg/kg, respectively, by oral administration in rat[2].

[References]

[1]. Xiong L, et al. Alkaloids isolated from the lateral root of Aconitum carmichaelii. Molecules. 2012 Aug 20;17(8):9939-46.

[2]. Li YX, et al. Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2014 Dec;28(12):1707-13.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
596.9±50.0 °C at 760 mmHg

[ Melting Point ]:
206-207ºC

[ Molecular Formula ]:
C₂₄H₃₉NO₇

[ Molecular Weight ]:
453.569

[ Flash Point ]:
314.8±30.1 °C

[ Exact Mass ]:
453.272644

[ PSA ]:
111.85000

[ LogP ]:
-1.32

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.617

[ Storage condition ]:
2-8C

Related Compounds

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