MEGESTROL ACETATE + ETHINYLO-ESTRADIOL
Names
Chemical & Physical Properties
[ Molecular Formula ]:
C44H56O6
[ Molecular Weight ]:
680.91200
[ Exact Mass ]:
680.40800
[ PSA ]:
100.90000
[ LogP ]:
8.18790
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4140000
- CHEMICAL NAME :
- Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-, acetate mixed with 19-nor-17-alpha- pregna-1,3,5(10)-trien-2-yne-3,17-diol
- CAS REGISTRY NUMBER :
- 8064-66-2
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C24-H32-O4.C20-H24-O2
- MOLECULAR WEIGHT :
- 681.00
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 10584 ug/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - normocytic anemia
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,273,1980
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 41 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,496,1975 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2430 ug/kg
- SEX/DURATION :
- female 30 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,1318,1963
Related Compounds
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