Paeoniflorigenone

Names

[ Name ]:
Paeoniflorigenone

[Synonym ]:
[(1S,3R,6S,8S,10S)-8-Hydroxy-3-methyl-5-oxo-2,9-dioxatricyclo[4.3.1.0]dec-10-yl]methyl benzoate
2,5-Methano-1,3-benzodioxol-6(5H)-one, 8-[(benzoyloxy)methyl]tetrahydro-3a-hydroxy-7a-methyl-, (2S,3aS,5S,7aR,8S)-

Biological Activity

[Description]:

Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

Paeoniflorigenone (0-30 μM; 0-72 hours) significantly decreases the cell proliferation of tumor cell lines and inhibits the proliferation of normal cell lines[1]. Paeoniflorigenone (0-30 μM; 24-72 hours) significantly induces apoptotic DNA fragmentation selectively in tumor cells[1]. Cell Proliferation Assay[1] Cell Line: TIG-1, 3T3-L1, HL60, Jurkat and HeLa cells Concentration: 0-30 μM Incubation Time: 0-72 hours Result: Significantly decreased the cell proliferation of tumor cell lines and inhibited the proliferation of normal cell lines. Apoptosis Analysis[1] Cell Line: TIG-1 and 3T3-L1 (normal cells), HL60, Jurkat, and HeLa cells (tumor cells) Concentration: 0, 1, 3, 10, 30 μM Incubation Time: 24 and 72 hours Result: Induced DNA fragmentation in three tumor cell lines, but not in two normal cell lines.

[References]

[1]. Huang Y, et al. Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex. Biosci Biotechnol Biochem. 2017;81(6):1106-1113.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
481.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₈O₆

[ Molecular Weight ]:
318.321

[ Flash Point ]:
177.1±22.2 °C

[ Exact Mass ]:
318.110352

[ PSA ]:
82.06000

[ LogP ]:
2.87

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.605

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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