Apocynin-d3

Names

[ Name ]:
Apocynin-d3

[Synonym ]:
Acetoguaiacon-d3
Apocynine-d3
1-(4-hydroxy-3-(d3)methoxyphenyl)ethanone
Acetoguaicone-d3
2-Methoxy-4-acetylphenol-d3
Acetovanillone-d3
4-Acetyl-2-methoxyphenol-d3
Apocynin-d3
4-Acetylguaiacol-d3
Acetoguaiacone-d3

Biological Activity

[Description]:

Apocynin-d3 is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102.

[3]. Stefanska J, et al. Mediators Inflamm, 2008, 106507.

[4]. Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 181(5):636-48.