SirReal1

Names

[ Name ]:
SirReal1

[Synonym ]:
N-(5-benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide
Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(phenylmethyl)-2-thiazolyl]-
N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetamide

Biological Activity

[Description]:

A novel potent, selective Sirt2 inhibitor with IC50 of 3.745 uM; displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM).

[References]

References 1. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. View Related Products by Target Sirtuin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₈H₁₈N₄OS₂

[ Molecular Weight ]:
370.492

[ Exact Mass ]:
370.092194

[ LogP ]:
4.60

[ Index of Refraction ]:
1.661

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.