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Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]-

Names

[ CAS No. ]:
79514-49-1

[ Name ]:
Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]-

[Synonym ]:
2-acetylpyridine-N,N-dimethylselenosemicarbazone
2-acetylpyridine 4,4-dimethyl-3-selenosemicarbazone
2-Acetylpyridine 4,4-dimethylselenosemicarbazone

Biological Activity

[Description]:

Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Zaynab Al-Eisawi, et al. Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. J Med Chem. 2016 Jan 14;59(1):294-312.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H15N4Se

[ Molecular Weight ]:
270.21300

[ Exact Mass ]:
271.04600

[ PSA ]:
40.52000

[ LogP ]:
0.71610

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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