9-Oxo-10,11-dehydroageraphorone

Names

[ Name ]:
9-Oxo-10,11-dehydroageraphorone

[Synonym ]:
2,6-Naphthalenedione, 1,3,4,4a,5,8a-hexahydro-4,7-dimethyl-1-(1-methylethylidene)-, (4R,4aS,8aR)-
(4R,4aS,8aR)-1-Isopropylidene-4,7-dimethyl-1,3,4,4a,5,8a-hexahydro-2,6-naphthalenedione

Biological Activity

[Description]:

Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Apoptosis >> Caspase

[In Vitro]

Euptox A (0-2 μg/mL, 48 h) 有效抑制HeLa细胞增殖[1]。 Euptox A（0-50 μg/mL，24 小时）阻止细胞周期从 S 期到 G2/M 期的转变[1]。 Euptox A 在体外以剂量依赖的方式对人肺癌 A549、HeLa 和 Hep-2 细胞系表现出显着的抗肿瘤活性[1]。 Euptox A 在体外对 S.scabiei 和P. cuniculi 表现出高度杀螨活性[1]。

[References]

[1]. Liao F, et al. Induction and mechanism of HeLa cell apoptosis by 9-oxo‑10, 11-dehydroageraphorone from Eupatorium adenophorum. Oncol Rep. 2015 Apr;33(4):1823-7.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
373.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₀O₂

[ Molecular Weight ]:
232.32

[ Flash Point ]:
140.3±24.9 °C

[ Exact Mass ]:
232.146332

[ PSA ]:
34.14000

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.508

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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