TASIN-1

Names

[ Name ]:
TASIN-1

[Synonym ]:
1,4'-Bipiperidine, 1'-[(4-methoxyphenyl)sulfonyl]-4-methyl-
1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine

Biological Activity

[Description]:

TASIN-1 is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 represents a potential therapeutic strategy for prevention and intervention in CRC with mutant APC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Zhang L, et al. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci Transl Med. 2016 Oct 19;8(361):361ra140.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
480.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₈N₂O₃S

[ Molecular Weight ]:
352.491

[ Flash Point ]:
244.1±31.5 °C

[ Exact Mass ]:
352.182068

[ LogP ]:
4.12

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.557

Related Compounds

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