ASP 2905

Names

[ Name ]:
ASP 2905

[Synonym ]:
1,3,5-Triazine-2,4,6-triamine, N2-(4-fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-
N2-(4-Fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine

Biological Activity

[Description]:

ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM; displays minimally bound with low affinities to 55 transmembrane proteins; decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM; reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats. Alzheimer Disease Phase 1 Discontinued

[References]

References 1. Takahashi S, et al. Eur J Pharmacol. 2017 Sep 5;810:26-35. View Related Products by Target Potassium Channel Alzheimer Disease

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
600.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₇FN₈

[ Molecular Weight ]:
388.401

[ Flash Point ]:
317.0±34.3 °C

[ Exact Mass ]:
388.156006

[ LogP ]:
2.26

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.739

Related Compounds

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