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clofedanol

Names

[ CAS No. ]:
791-35-5

[ Name ]:
clofedanol

[Synonym ]:
3-Dimethylamino-1-phenyl-1-<1-chlor-phenyl>-propanol-(1)
Clofedanolum
DL-1-Phenyl-1-(2-chlor-phenyl)-3-dimethylamino-propanol-(1)
Clophedianol base
1-(2-Chlor-phenyl)-3-dimethylamino-1-phenyl-propan-1-ol
Ulo base
Chlofedanol
Dencyl
Clofedano
Tussistop
chlophedianol
chlophedianol hydrochloride
Clofedanol
Calmotusin

Biological Activity

[Description]:

Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[References]

[1]. Boyd EM, et al. Chlophedianol Hydrochloride: A New Antitussive Agent. Can Med Assoc J. 1960 Dec 17;83(25):1298-301.

[2]. Paul IM. Therapeutic options for acute cough due to upper respiratory infections in children. Lung. 2012 Feb;190(1):41-4.

Chemical & Physical Properties

[ Melting Point ]:
120°

[ Molecular Formula ]:
C17H20ClNO

[ Molecular Weight ]:
289.80000

[ Exact Mass ]:
289.12300

[ PSA ]:
23.47000

[ LogP ]:
3.52760

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DC7599500
CHEMICAL NAME :
Benzhydrol, 2-chloro-alpha-(2-(dimethylamino)ethyl)-
CAS REGISTRY NUMBER :
791-35-5
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C17-H20-Cl-N-O
MOLECULAR WEIGHT :
289.83
WISWESSER LINE NOTATION :
GR BXQR&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,476,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,316,1989

Related Compounds

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