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NGI 1

Names

[ CAS No. ]:
790702-57-7

[ Name ]:
NGI 1

[Synonym ]:
MFCD06358908
5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(1-pyrrolidinyl)benzamide
Benzamide, 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-

Biological Activity

[Description]:

NGI-1 is a cell permeable inhibitor.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[In Vitro]

NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed. In controls EGFR is biotinylated, consistent with its plasma membrane expression, but in NGI-1 treated cells the EGFR is predominantly found in the non-biotinylated intracellular fraction suggesting a change in cellular localization[1].

[References]

[1]. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C17H22N4O3S2

[ Molecular Weight ]:
394.512

[ Exact Mass ]:
394.113342

[ LogP ]:
2.75

[ Index of Refraction ]:
1.634

[ Storage condition ]:
-20℃

Related Compounds

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