ITMN 4077

Names

[ CAS No. ]:
790305-05-4

[ Name ]:
ITMN 4077

Biological Activity

[Description]:

ITMN 4077 is a macrocyclic inhibitor against Hepatitis C Virus (HCV) NS3 protease (EC50: 2131 nM)[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease

[Target]

HCV NS3 protease[2]

[References]

[1]. Rajagopalan R, et al. Inhibition and binding kinetics of the hepatitis C virus NS3 protease inhibitor ITMN-191 reveals tight binding and slow dissociative behavior. Biochemistry. 2009 Mar 24;48(11):2559-68.

[2]. Jiang Y, et al. Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease. J Med Chem. 2014 Mar 13;57(5):1753-69.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₄₀N₄O₈S

[ Molecular Weight ]:
568.6828

Related Compounds

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