2′-Deoxy-2′-fluoroguanosine

Names

[ Name ]:
2′-Deoxy-2′-fluoroguanosine

[Synonym ]:
2'-fluorodeoxyguanisine
2'-Fluoro-2'-deoxyguanosine
2'-fluorodeoxyguanosine
2'-fluoro guanosine
2'-fluoro-2',3'-dideoxyguanosine
2'-Dfgs
2'-Deoxy-2'-fluoroguanosine
Guanosine,2'-deoxy-2'-fluoro
Guanosine, 2'-deoxy-2'-fluoro-

Biological Activity

[Description]:

2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of <0.35 μM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[Target]

EC90: <0.35 μM (influenza virus A and B)[1]

[References]

[1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8.

[2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7.

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Molecular Formula ]:
C₁₀H₁₂FN₅O₄

[ Molecular Weight ]:
285.232

[ Exact Mass ]:
285.087341

[ PSA ]:
140.27000

[ LogP ]:
-0.53

[ Appearance of Characters ]:
Powder | White to Off-white

[ Index of Refraction ]:
1.876

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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