m-PEG4-sulfonic acid

Names

[ CAS No. ]:
787524-78-1

[ Name ]:
m-PEG4-sulfonic acid

[Synonym ]:
MFCD29042380
2,5,8,11-Tetraoxatridecane-13-sulfonic acid

Biological Activity

[Description]:

m-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₉H₂₀O₇S

[ Molecular Weight ]:
272.316

[ Exact Mass ]:
272.092987

[ LogP ]:
-2.95

[ Index of Refraction ]:
1.464

m-PEG4-sulfonic acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds