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excisanin A

Names

[ CAS No. ]:
78536-37-5

[ Name ]:
excisanin A

[Synonym ]:
(1α,5β,7α,8α,9β,10α,12α,13α,14R)-1,7,12,14-Tetrahydroxykaur-16-en-15-one

Biological Activity

[Description]:

Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Qin J, et al. A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling. Life Sci. 2013 Nov 4;93(18-19):655-63.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
558.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H30O5

[ Molecular Weight ]:
350.45

[ Flash Point ]:
305.8±26.6 °C

[ Exact Mass ]:
350.209320

[ PSA ]:
97.99000

[ LogP ]:
0.13

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.600

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds