2-Methyl-5-HT

Names

[ Name ]:
2-Methyl-5-HT

[Synonym ]:
2-Methyl-5-HT
Lopac-M-109
3-(2-aminoethyl)-2-methyl-1H-indol-5-ol
2-Me 5-HT
2-Methyl-5-hydroxytryptamine
Tocris-0558

Biological Activity

[Description]:

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1].

[Target]

5-HT3 Receptor

[In Vivo]

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) significantly decreases time of immobility thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.

[References]

[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.

Chemical & Physical Properties

[ Density]:
1.242g/cm3

[ Boiling Point ]:
420.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₄N₂O

[ Molecular Weight ]:
190.24200

[ Flash Point ]:
208.4ºC

[ Exact Mass ]:
190.11100

[ PSA ]:
62.04000

[ LogP ]:
2.38340

[ Index of Refraction ]:
1.687

Safety Information

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%