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SBI-477

Names

[ CAS No. ]:
781628-99-7

[ Name ]:
SBI-477

Biological Activity

[Description]:

SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain–containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

MondoA[1]


[References]

[1]. Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25N3O6S

[ Molecular Weight ]:
483.54

Related Compounds